Coupled effects of channels and synaptic dynamics in stochastic modelling of healthy and Parkinson's-disease-affected brains

<abstract> <p>Our brain is a complex information processing network in which the nervous system receives from environment to quickly react incoming events or learns experience sharp our memory. In system, states translate collective activities of neurons interconnected via synaptic connections. this paper, we study coupled effects channels and dynamics under stochastic influence healthy cells with applications Parkinson's disease (PD). particular, investigate random inputs subthalamic nucleus (STN) cell membrane potential model. The STN bursting phenomena parkinsonian hypokinetic motor symptoms are closely connected, as electrical chemical maneuvers modulating bursts sufficient ameliorate mimic deficits. Deep stimulation (DBS) an important surgical technique used treatment improve PD symptoms. Our numerical results show that strongly affect spiking neuron not only case but also presence DBS treatment. Specifically, existence refractory period together input current may substantially increased irregularity spike trains output neurons.</p> </abstract>